Abstract:
Adipose tissue-derived stem cells (ADSCs) are genetically engineered seed cells with immunomodulatory effects, widely used in the treatment of autoimmune diseases. This article focuses on the immunomodulatory effects of adipose tissue-derived stem cells on CD4+ T cell subsets, including T helper cell (Th) 1, 2, 17 and regulatory T cell (Treg), and its clinical significance in the treatment of multiple sclerosis.
Key words:
Mesenchymal stem cells,
Adipocytes,
T-lymphocytes,
Multiple sclerosis,
Encephalomyelitis, autoimmune, experimental,
Review
摘要： 脂肪间充质干细胞是基因工程的种子细胞，具有免疫调节能力，可广泛应用于多种自身免疫性疾病的治疗。本文重点介绍脂肪间充质干细胞对CD4+T 细胞各亚群的免疫调节作用及其在多发性硬化治疗中的临床意义。
关键词:
间质干细胞,
脂细胞,
T 淋巴细胞,
多发性硬化,
脑脊髓炎, 自身免疫性, 实验性,
综述
XIE Yong-lin, BI Yong, ZHANG Xu. Significance of adipose tissue-derived stem cells regulate CD4+ T cell immune in the treatment of multiple sclerosis[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2014, 14(10): 854-857.
谢甬淋, 毕涌, 张旭. 脂肪间充质干细胞调节CD4+T 细胞免疫在多发性硬化治疗中的意义[J]. 中国现代神经疾病杂志, 2014, 14(10): 854-857.