Abstract: Objective To assess the efficacy of shortened neuropsychological tests for discernment of mild cognitive impairment (MCI) by comparing 3 shortened tests [Animal Fluency Test (AFT), Color Trail Test (CTT) B and Bells Test (BT)], and to provide information for developing brief cognitive screening tool. Methods One hundred and twenty MCI patients and 180 cognitive normal controls (NC) were assessed by a set of standardized comprehensive neuropsychological evaluation including Mini-Mental State Examination (MMSE), Auditory Verbal Learning Test (AVLT), Logical Memory Test (LM), Rey-Osterrieth Complex Figure Test (ROCFT), Clock Drawing Test (CDT), AFT, Boston Naming Test (BNT), Cancellation Test (CT), Digit Span Test (DS), Stroop Color-Word Test (CWT), CTT A and B, Similarity Test, BT, Clinical Dementia Rating Scale (CDR), Activities of Daily Living Scale (ADL), Self -Rating Depression Scale (SDS) and Geriatric Depression Scale (GDS). Results 1) AFT: the greatest difference was seen between MCI (12.65 ± 2.83) and NC (14.93 ± 2.49) in 45 s fluency test version (t = 7.315, P = 0.000). 2) CTT: there was significant difference between MCI (9.28 ± 3.53) and NC (13.43 ± 4.12) in terms of 1 min CTT version (t = 9.356, P = 0.000), and in which the differential efficacy nearly approached the full length version. 3) BT: there were significant differences between MCI and NC groups in all 4 scores including accuracy score, time, post-advising accuracy score and total time (t = 4.164, 3.427, 3.616, 5.102, respectively; P = 0.000, for all). The average time for recancellation was 100 s. However, discerning efficacy was not obviously improved after recancellation. Conclusion Appropriately shortened version of Animal Fluency Test, Color Trail Test and Bells Test prensents the same discerning efficacy for MCI as the original versions. It is feasible for MCI screening.

Key words: Cognition disorders, Neuropsychological tests

摘要： 目的   通过比较动物流畅性测验、着色连线测验B 和搜钟测验的时间截断点评分，分析缩短测验时间对轻度认知损害识别力的影响，从而为编制快速识别方法提供依据。方法   分别采用多项神经心理学测验量表对120 例轻度认知损害患者的总体认知水平、记忆力、结构能力、语言能力、注意力、执行能力，以及日常生活活动能力和抑郁状态进行评价，以分析缩短测验时间对轻度认知损害鉴别力的影响。结果   动物流畅性测验，以45 s 时轻度认知损害组（12.65 ± 2.83）与正常对照组（14.93 ±2.49）之间的鉴别力差异最大（t = 7.315，P = 0.000）。着色连线测验第一分钟结束时，轻度认知损害组（9.28 ± 3.53）与正常对照组（13.43 ± 4.12）差异有统计学意义（t = 9.356，P = 0.000），其鉴别力与完成着色连线测验全长的耗时数指标十分接近。两组受试者搜钟测验自发正确数目及自发完成时间、劝告后划消的总正确数目及总完成时间比较，差异均有统计学意义（t = 4.164，3.427，3.616，5.102；均P = 0.000），劝告后划消时间平均需要100 s，但是复搜对轻度认知损害的识别能力并无明显改善。结论   适当缩短动物流畅性测验、着色连线测验B 和搜钟测验的检测时间并不影响对轻度认知损害的识别力，提示编制快速识别轻度认知损害的成套神经心理学测验量表具有可行性。

关键词: 认知障碍, 神经心理学测验