Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2021, Vol. 21 ›› Issue (1): 34-40. doi: 10.3969/j.issn.1672-6731.2021.01.008

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Research advances in the association of post-stroke cognitive impairment and gastrointestinal microbiome imbalance

SONG Xin-na, ZHANG Ming-si, YIN Jia   

  1. Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
  • Received:2021-01-14 Online:2021-01-25 Published:2021-01-22
  • Supported by:

    This study was supported by the National Natural Science Foundation of China (No. 81671171).

脑卒中后认知功能障碍与肠道菌群紊乱研究进展

宋欣娜, 张铭思, 尹恝   

  1. 510515 广州,南方医科大学南方医院神经内科
  • 通讯作者: 尹恝,Email:jiajiayin@139.com
  • 基金资助:

    国家自然科学基金资助项目(项目编号:81671171)

Abstract:

Post-stroke cognitive impairment (PSCI) is one of the most important factors leading to post-stroke disability. In recent years, studies have shown that patients with PSCI have gastrointestinal microbiome imbalance. Besides, gastrointestinal microbiome also plays an important role in the occurrence and development of PSCI. As a consequence, this research reviews the progress on the relationship between the PSCI and the gastrointestinal microbiome, in order to provide a new perspective for the prevention, the treatment and research direction of PSCI.

Key words: Stroke, Cognition disorders, Gastrointestinal microbiome, Fecal microbiota transplantation, Review

摘要:

脑卒中后认知功能障碍是脑卒中致残的重要原因之一。新近研究发现,脑卒中后认知功能障碍患者出现明显的肠道菌群紊乱,提示肠道菌群也在脑卒中后认知功能障碍的发生发展中起重要作用。本文拟就脑卒中后认知功能障碍与肠道菌群的相关研究进行综述,为其预防、治疗和研究方向提供新视角。

关键词: 卒中, 认知障碍, 胃肠道微生物组, 粪便微生物群移植, 综述