Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2020, Vol. 20 ›› Issue (12): 1032-1036. doi: 10.3969/j.issn.1672-6731.2020.12.002

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Advances in neural circuit mechanism in Parkinson's disease

XIONG Chi, NIU Chao-shi   

  1. Department of Neurosurgery, The First Affiliated Hospital of University of Science and Technology of China;Anhui Provincial Stereotactic Neurosurgical Institute;Anhui Province Key Laboratory of Brain Function and Brain Disease, Hefei 230001, Anhui, China
  • Received:2020-12-17 Online:2020-12-25 Published:2020-12-31
  • Supported by:

    This study was supported by the Special Fund Project of Central Government Guiding Local Science and Technology Innovation (No. 2019b07030001).

帕金森病神经环路机制研究进展

熊赤, 牛朝诗   

  1. 230001 合肥, 中国科学技术大学附属第一医院神经外科 安徽省脑立体定向神经外科研究所 脑功能与脑疾病安徽省重点实验室
  • 通讯作者: 牛朝诗,Email:niuchaoshi@163.com
  • 基金资助:

    中央引导地方科技创新专项项目(项目编号:2019b07030001)

Abstract:

Parkinson's disease (PD) is a common neurodegenerative disease with strong heterogeneity of clinical symptoms and progressive aggravation. The core pathological feature is the apoptosis of dopaminergic neurons in substantia nigra and striatum, but this pathological feature can only explain part of the symptom. With the development of electrophysiological recording, fMRI, optogenetics and other technologies, it has been found that neural circuit dysfunction after dopaminergic neuron apoptosis is an important mechanism for the occurrence and development of PD, as well as many therapeutic measures such as deep brain stimulation (DBS) intervention target. This article reviews the research progress of PD neural circuit mechanism in recent years, including common symptoms of PD, neural circuit models, and abnormal electrical activity patterns, to provide ideas for clinical research.

Key words: Parkinson disease, Neurons, Basal ganglia, Deep brain stimulation, Review

摘要:

帕金森病是临床常见的神经退行性疾病,临床症状异质性强,病情呈渐进性加重,其病理核心特征为黑质纹状体多巴胺能神经元凋亡,但这一病理特征仅能解释部分症状。随着神经电生理监测、fMRI、光遗传学等技术的发展,目前普遍认为,多巴胺能神经元凋亡诱发的神经环路功能障碍是帕金森病发生发展的重要机制,也是脑深部电刺激术等多种治疗措施的干预靶点。本文对近年帕金森病神经环路机制研究进展如帕金森病常见症状、神经环路模型,以及异常神经电活动模式等进行概述,以为临床研究提供思路。

关键词: 帕金森病, 神经元, 基底神经节, 深部脑刺激法, 综述