The achievement and prospect of deep brain stimulation for the treatment of movement disorders

doi:10.3969/j.issn.1672-6731.2020.12.001

Abstract

Abstract:

Deep brain stimulation (DBS) was first used in the treatment of essential tremor in 1987, and later used in the treatment of advanced Parkinson's disease (PD), drug-refractory dystonia, other types of tremor and Tourette's syndrome, which can reduce the clinical symptoms and improve quality of life of patients for a long time, as a major progress in surgical treatment of movement disorders in past 30 years. However, there are also limitations that can not effectively improve the axial system symptoms of PD, secondary dystonia, or related side effects such as cognitive impairment and balance disorder. In recent years, the exploration of new targets and innovation of DBS equipment have further promoted the treatment of DBS for movement disorders. This article reviews relevant research to provide clinical guidance.

Key words: Parkinson disease, Dystonia, Tremor, Tourette syndrome, Huntington disease, Deep brain stimulation, Review

摘要：

脑深部电刺激术最早用于治疗特发性震颤，之后逐渐用于中晚期帕金森病、药物难治性肌张力障碍、其他类型震颤和抽动秽语综合征的治疗，可长期改善临床症状、提高生活质量，是近30余年运动障碍性疾病外科治疗的重大进展。然而脑深部电刺激术存在无法有效改善帕金森病中轴系统症状和继发性肌张力障碍等局限，以及诱发认知功能障碍和步态平衡障碍等不良事件。近年来，脑深部电刺激术刺激靶点和设备技术的革新进一步推动了该疗法在运动障碍性疾病中的应用。

关键词: 帕金森病, 张力失调, 震颤, 多动秽语综合征, 杭廷顿病, 深部脑刺激法, 综述

NIU Chao-shi, XIONG Chi. The achievement and prospect of deep brain stimulation for the treatment of movement disorders[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2020, 20(12): 1027-1031.

牛朝诗, 熊赤. 脑深部电刺激术治疗运动障碍性疾病现状与展望[J]. 中国现代神经疾病杂志, 2020, 20(12): 1027-1031.

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