The situations and strategies of amyloid-&beta;-directed passive immunotherapy for Alzheimer's disease

doi:10.3969/j.issn.1672-6731.2019.12.014

Abstract

Abstract:

It is widely believed that amyloid β-protein (Aβ) plays a core role in the pathogenesis of Alzheimer's disease (AD). Thus A β is one of main targets in the therapeutic explorations for AD. Currently, clearance of A β by passive immunotherapy is an important strategy for the treatment of AD. However, no consistent conclusions have been obtained from various clinical trails. We summarize the current situations of A β-directed passive immunotherapy for AD, and speculate that the failure of A β-directed passive immunotherapy for AD may be related to the intrinsic characteristics of A β-IgG glycosylation. Therefore, modifications of N-glycosylation on the Fc domain of A β-IgG and using a sequential administration mode of proinflammation-antiinflammation may be an effective strategy for passive immunotherapy for AD.

Key words: Alzheimer disease, Amyloid beta-peptides, Immunization, passive, Review

摘要：

β-淀粉样蛋白（Aβ）既是阿尔茨海默病发病机制中的重要病因，又是治疗的关键靶点之一。采取被动免疫途径清除脑组织Aβ是目前颇受临床关注的治疗策略。然而，各项临床试验至今尚未获得一致性的结论。对其研究现状的分析表明，Aβ被动免疫治疗失败的原因可能与Aβ-IgG免疫复合物所固有的糖基化修饰有关。因此，改良Aβ-IgG Fc片段N-糖基化修饰、采取促炎症反应-抗炎症反应序贯给药模式，可能是一种有效的被动免疫治疗策略。

关键词: 阿尔茨海默病, 淀粉样β肽类, 免疫法, 被动, 综述

LI Ya, ZHANG An-ni, WU Xu-ling, ZHAO Yan, CAI Gang, HE Dian. The situations and strategies of amyloid-β-directed passive immunotherapy for Alzheimer's disease[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2019, 19(12): 987-993.

李娅, 张安妮, 吴旭玲, 赵艳, 蔡刚, 贺电. β-淀粉样蛋白被动免疫治疗阿尔茨海默病的现状与策略[J]. 中国现代神经疾病杂志, 2019, 19(12): 987-993.

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URL: http://journal11.magtechjournal.com/cjcnn/EN/10.3969/j.issn.1672-6731.2019.12.014

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The situations and strategies of amyloid-β-directed passive immunotherapy for Alzheimer's disease

β-淀粉样蛋白被动免疫治疗阿尔茨海默病的现状与策略

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The situations and strategies of amyloid-β-directed passive immunotherapy for Alzheimer's disease

β-淀粉样蛋白被动免疫治疗阿尔茨海默病的现状与策略

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