Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2018, Vol. 18 ›› Issue (1): 30-35. doi: 10.3969/j.issn.1672-6731.2018.01.005

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The role of DISC1 gene in growth of neural stem cells and epileptogenesis

WU Wen-yue1, WU Qian2, XIAO Wen-biao1, LONG Hong-yu1, XIAO Bo1   

  1. 1Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hu'nan, China
    2Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China
  • Online:2018-01-25 Published:2018-01-29
  • Contact: XIAO Bo (Email: xiaobo_xy@126.com)
  • Supported by:

    This study was supported by the National Natural Science Foundation of China (No. 81071048).

DISC1 基因对神经干细胞生长发育及癫发生机制研究

吴文悦, 吴倩, 肖文彪, 龙泓羽, 肖波   

  1. 410008 长沙,中南大学湘雅医院神经内科(吴文悦,肖文彪,龙泓羽,肖波);650032 昆明医科大学第一附属医院神经内科(吴倩)
  • 通讯作者: 肖波(Email:xiaobo_xy@126.com)
  • 基金资助:

    国家自然科学基金资助项目(项目编号:81071048)

Abstract:

Disrupted in schizophrenia 1 (DISC1) is widely expressed in brain, and plays a role in multiple process of neurogenesis such as proliferation, migration, differentiation and maturation. DISC1 gene was found not only associated with mental disorders, such as schizophrenia, bipolar disorder and major depressive disorder, but also correlated with some neurological diseases, such as epilepsy. Our team have made efforts to clarify how DISC1 gene works in the regulation of neurogenesis and epileptogenesis. Here, we reviewed the DISC1 function on the development of neural stem cells (NSCs) and epileptogenesis.

Key words: DISC1 (not in MeSH), Neurons, Stem cells, Epilepsy, Review

摘要:

精神分裂症断裂基因1(DISC1)广泛表达于脑组织,对神经元生长发育的多个阶段,如增殖、迁移、分化和成熟均发挥调控作用。DISC1 基因不仅与精神分裂症、双相情感障碍和重度抑郁症等精神病的发病机制相关,还参与神经系统疾病,如癫的发生与发展。中南大学湘雅医院肖波教授研究团队致力于研究DISC1 基因及其相关蛋白在神经干细胞生长发育及癫发生发展中的调控作用。本文结合既往研究,展示我们研究团队相关成果,总结DISC1 基因及其相关蛋白在神经干细胞生长发育及癫发生发展中的分子生物学机制。

关键词: 精神分裂症断裂基因1(非MeSH 词), 神经元, 干细胞, 癫, 综述