Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2016, Vol. 16 ›› Issue (11): 774-778. doi: 10.3969/j.issn.1672-6731.2016.11.010

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A study on risk factors for mild vascular cognitive impairment in patients with lacunar infarct

JIANG Han1, ZENG Qian1, SONG Chun-jiang1, WU Bo2   

  1. 1Department of Neurology, the Sixth People's Hospital of Chengdu, Chengdu 610051, Sichuan, China
    2Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
  • Online:2016-11-25 Published:2016-11-27
  • Contact: WU Bo (Email: dr.bowu@hotmail.com)

腔隙性梗死患者轻度血管性认知损害危险因素分析

蒋晗, 曾倩, 宋春江, 吴波   

  1. 610051 四川省成都市第六人民医院神经内科(蒋晗,曾倩,宋春江);610041 成都,四川大学华西医院神经内科(吴波)
  • 通讯作者: 吴波(Email:dr.bowu@hotmail.com)

Abstract:

Objective  To study the risk factors for vascular cognitive impairment (VCI) after lacunar infarct (LACI).  Methods  A total of 138 patients with LACI were evaluated by Montreal Cognitive Assessment (MoCA), and divided into normal cognitive function group (normal, N = 55), mild cognitive impairment (MCI) group (mild, N = 73) and severe cognitive impairment group (severe, N = 10). Univariate and backward multivariate Logistic regression analysis were used to screen the risk factors for VCI after LACI.  Results  Logistic regression analysis showed that infarct in critical site (OR = 1.179, 95% CI: 0.870-2.472; P = 0.012) and white matter hyperintensity (WMH) Grade 3-4 (OR = 2.005, 95% CI: 0.910-4.502; P = 0.024) were independent risk factors for VCI in patients with LACI.  Conclusions  VCI in patients with LACI is related to multiple factors, in which infarct in critical site and WMH Grade 3-4 are independent risk factors.

Key words:

摘要:

目的 探讨腔隙性梗死后血管性认知损害的相关危险因素。方法 共138 例腔隙性梗死患者根据蒙特利尔认知评价量表分为认知功能正常55例、轻度认知功能障碍73例和重度认知功能障碍10 例,采用单因素和多因素后退法Logistic 回归分析筛查腔隙性梗死后血管性认知损害相关危险因素。结果 关键部位梗死灶(OR = 1.179,95%CI:0.870 ~ 2.472;P = 0.012)和脑白质高信号3 ~ 4 级(OR =2.005,95%CI:0.910 ~ 4.502;P = 0.024)是腔隙性梗死患者出现血管性认知损害的独立危险因素。结论 腔隙性梗死后血管性认知损害是多因素共同作用的结果,其中关键部位梗死灶和脑白质高信号3 ~4级是独立危险因素。

关键词: 脑梗死, 认知障碍, 危险因素, 回归分析