Abstract:
Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) antibody is a newly recognized autoantibody, which is associated with the use of statins and is considered as an immunological marker of necrotizing autoimmune myopathy (NAM). This article summarizes the discovery, laboratory tests and clinical significance of anti-HMGCR antibody.
Key words:
Hydroxymethylglutaryl CoA reductases,
Immunoassay,
Antilipemic agents,
Review
摘要：
抗3-羟基-3-甲基戊二酰辅酶A 还原酶抗体是新近发现的一种自身抗体，与他汀类调脂药密切相关，可以作为免疫性坏死性肌病的免疫学标志物。本文拟就该抗体的发现、检测方法和临床意义进行简要综述。
关键词:
羟甲基戊二酰基CoA 还原酶类,
免疫测定,
降血脂药,
综述
LUO Jing-jing, GAO Feng, WEN Jie-xi, HAO Hong-jun, GUO Jing, HUANG Yi-ning. Laboratory tests and clinical significance of anti-3-hydroxy-3-methylglutaryl coenzyme A reductase antibody[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2016, 16(9): 573-575.
罗晶晶, 高枫, 闻洁曦, 郝洪军, 郭晶, 黄一宁. 抗3-羟基-3-甲基戊二酰辅酶A 还原酶抗体实验室检测及临床意义[J]. 中国现代神经疾病杂志, 2016, 16(9): 573-575.