Abstract: A total of 153 patients with acute ischemic stroke were divided into diabetes group and non-diabetes group. Baseline characteristics and prognosis were observed and compared between patients of the 2 groups. The correlation between diabetes and outcome after intravenous thrombolysis was analyzed by multivariate stepwise Logistic regression analysis. The results showed that the patients in diabetes group accounted for less favorable outcome than that in non-diabetes group (26.83% vs 41.96%; χ² = 11.692, P = 0.001) at 90 d after thrombolytic treatment. Logistic regression analysis indicated that diabetes was relevant to unfavorable outcome of ischemic stroke (OR = 1.224, 95% CI: 1.034-1.449; P = 0.019). The results illustrate that diabetes is highly relevant to unfavorable outcome of thrombolytic patients with acute ischemic stroke.

Key words: Diabetes mellitus, Brain ischemia, Tissue plasminogen activator, Regression analysis

摘要： 根据是否合并糖尿病将153 例急性缺血性卒中患者分为糖尿病组和非糖尿病组，观察两组患者一般特征和预后，多因素逐步法Logistic 回归分析评价糖尿病与静脉溶栓预后关联性。结果显示，糖尿病组患者溶栓治疗后90 d 获得良好预后比例低于非糖尿病组（26.83%对41.96%；χ² = 11.692，P = 0.001）；Logistic 回归分析提示糖尿病与缺血性卒中预后不良存在关联性（OR = 1.224，95%CI：1.034 ~ 1.449；P = 0.019）。糖尿病与急性缺血性卒中静脉溶栓治疗患者预后不良呈高度相关。

关键词: 糖尿病, 脑缺血, 组织型纤溶酶原激活物, 回归分析