Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2014, Vol. 14 ›› Issue (10): 854-857. doi: 10.3969/j.issn.1672-6731.2014.10.005

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Significance of adipose tissue-derived stem cells regulate CD4+ T cell immune in the treatment of multiple sclerosis

XIE Yong-lin, BI Yong, ZHANG Xu   

  1. Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
  • Online:2014-10-25 Published:2014-10-14
  • Contact: ZHANG Xu (Email: drzhangxu@live.cn)
  • Supported by:

    This study was supported by National Science Foundation of Zhejiang Province (No. Y2101091, LY13H090010).

脂肪间充质干细胞调节CD4+T 细胞免疫在多发性硬化治疗中的意义

谢甬淋, 毕涌, 张旭   

  1. 325000 温州医科大学附属第一医院神经内科
  • 通讯作者: 张旭 (Email:drzhangxu@live.cn)
  • 基金资助:

    浙江省自然科学基金资助项目(项目编号:Y2101091);浙江省自然科学基金资助项目(项目编号:LY13H090010)

Abstract: Adipose tissue-derived stem cells (ADSCs) are genetically engineered seed cells with immunomodulatory effects, widely used in the treatment of autoimmune diseases. This article focuses on the immunomodulatory effects of adipose tissue-derived stem cells on CD4+ T cell subsets, including T helper cell (Th) 1, 2, 17 and regulatory T cell (Treg), and its clinical significance in the treatment of multiple sclerosis.

Key words: Mesenchymal stem cells, Adipocytes, T-lymphocytes, Multiple sclerosis, Encephalomyelitis, autoimmune, experimental, Review

摘要: 脂肪间充质干细胞是基因工程的种子细胞,具有免疫调节能力,可广泛应用于多种自身免疫性疾病的治疗。本文重点介绍脂肪间充质干细胞对CD4+T 细胞各亚群的免疫调节作用及其在多发性硬化治疗中的临床意义。

关键词: 间质干细胞, 脂细胞, T 淋巴细胞, 多发性硬化, 脑脊髓炎, 自身免疫性, 实验性, 综述