Abstract: Objective  To detect the levels of serum lipid and endothelin-1 (ET-1) in acute period migraine, and to observe the correlation between them.  Methods  The serum lipid level in healthy control group (N = 42) and migraine group (N = 95) was detected by automatic biochemical detector and serum ET-1 level of two groups was measured by radioimmunoassay method.  Results  Compared with healthy control group, the levels of total cholesterol (TC), trighyceride (TG), low-density lipoprotein cholesterol (LDL-C) and ET-1 in migraine group, especially patients with dyslipidemia, were significantly higher (P < 0.05, for all), while the difference of high?density lipoprotein cholesterol (HDL-C) level had no statistical significance (P > 0.05). Serum ET-1 content in migraine group was positively correlated with the levels of TC (r_s = 0.208, P = 0.043), TG (r_s = 0.331, P = 0.001), LDL-C (r_s = 0.217, P = 0.035), but was not correlated with HDL-C level (r_s = -0.099, P = 0.341).  Conclusion  The changes of serum lipid and ET-1 level play an important role in the process of migraine attacks. Serum ET-1 has positive correlation with TG, TC, LDL-C levels, suggesting the correlation of serum lipid and ET-1 in acute period migraineurs and effective control for serum lipid has important significance for the prevention of migraine and cardiovascular diseases.

Key words: Migraine disorders, Endothelins, Hyperlipidemias

摘要： 检测偏头痛患者血脂和内皮素-1 表达水平，观察二者之间相关性。结果显示，偏头痛组患者，尤其是伴血脂异常者血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇及内皮素-1 水平均高于正常对照组（P < 0.05）；偏头痛组患者血清内皮素-1 与总胆固醇（r_s = 0.208，P = 0.043）、甘油三酯（r_s = 0.331，P =0.001）、低密度脂蛋白胆固醇（r_s = 0.217，P = 0.035）呈正相关关系，而与高密度脂蛋白胆固醇无关联性（r_s = -0.099，P = 0.341）。提示血脂及内皮素-1 在偏头痛发作过程中起重要作用，了解血脂与内皮素-1 之间的相关关系，有效控制血脂水平，对预防偏头痛具有重要意义。

关键词: 偏头痛, 内皮缩血管肽类, 高脂血症