肠道菌群对难治性癫痫发病的影响

doi:10.3969/j.issn.1672-6731.2023.02.001

摘要/Abstract

摘要： 肠道菌群通过微生物群-肠道-脑轴调节神经功能和行为，并参与多种神经系统疾病的发病机制。癫痫患者肠道菌群结构和功能发生明显变化，但尚未得出一致性变化的菌群。本文概述癫痫患者肠道菌群改变、肠道菌群与癫痫的关系、肠道菌群的抗癫痫作用、微生物群-肠道-脑轴在癫痫发病中潜在机制方面研究进展，以为难治性癫痫提供新的治疗靶点。

关键词: 癫痫, 胃肠道微生物组, 综述

Abstract: The gut microbiota could regulate brain function and behavior via microbiota-gut-brain axis and is associated with the pathogenesis of various neurological diseases. Significant alteration of gut microbiota is seen in patients with epilepsy, but consistent microbiota change has not yet been obtained. We aimed to summarize the changes of gut microbiota in patients with epilepsy, the relationship between gut microbiota and epilepsy, the anti-seizure effect of gut microbiota, and the potential mechanism of gut microbiota-gut-brain axis in the pathogenesis of epilepsy, which would help to provide new therapeutic targets for the treatment of refractory epilepsy.

Key words: Epilepsy, Gastrointestinal microbiome, Review

洪桢. 肠道菌群对难治性癫痫发病的影响[J]. 中国现代神经疾病杂志, 2023, 23(2): 69-77.

HONG Zhen. The impact of gut microbiota on the development of refractory epilepsy[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2023, 23(2): 69-77.

http://journal11.magtechjournal.com/cjcnn/CN/Y2023/V23/I2/69

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The impact of gut microbiota on the development of refractory epilepsy

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2 肠道菌群对难治性癫痫发病的影响

The impact of gut microbiota on the development of refractory epilepsy

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