动脉自旋标记测定脑血流量在阿尔茨海默病研究中的进展

doi:10.3969/j.issn.1672-6731.2023.01.006

摘要/Abstract

摘要： 脑血流量变化与阿尔茨海默病进程密切相关。动脉自旋标记（ASL）以血液中水质子作为内源性对比剂获得脑血流量，以其无创性、安全等优点在阿尔茨海默病研究中备受关注，但在各项研究中的实施方案尚缺乏一致性，且受样本量和人群队列选择的限制，研究结论不尽一致，导致其在阿尔茨海默病研究中的应用较为局限。本文综述ASL测定脑血流量与阿尔茨海默病病程、病理学标志物、血管病理负担、载脂蛋白Eε4（ApoEε4）等位基因及认知功能障碍进展之间的研究进展，为推动ASL在阿尔茨海默病研究中的应用提供指导。

关键词: 阿尔茨海默病, 脑血管循环, 磁共振成像, 生物标记, 综述

Abstract: Cerebral blood flow (CBF) changes are closely related to Alzheimer's disease (AD). Arterial spin labeling (ASL) uses water proton in blood as an endogenous contrast agent to obtain CBF, which has attracted must attention in AD studies due to its advantages of non-invasiveness and safety. However, there is still a lack of uniformity in the implementation of ASL in clinical settings, and limited by sample size and different population cohorts, research results may be different or lack of universality, which lead to the fact that this technology has not yet been widely applied in AD. This article reviews the new research progress on the correlation between CBF measured by ASL and AD disease process, pathologic biomarkers, vascular pathological burden, apolipoprotein E ε4 (ApoEε4) gene, and cognitive impairment development, in order to provide guidance for the clinical application of ASL in AD.

Key words: Alzheimer disease, Cerebrovascular circulation, Magnetic resonance imaging, Biomarkers, Review

孙梦凡, 姜季委, 王艳丽, 张源, 徐俊. 动脉自旋标记测定脑血流量在阿尔茨海默病研究中的进展[J]. 中国现代神经疾病杂志, 2023, 23(1): 29-34.

SUN Meng-fan, JIANG Ji-wei, WANG Yan-li, ZHANG Yuan, XU Jun. Research progress of cerebral blood flow measured by arterial spin labeling in Alzheimer's disease[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2023, 23(1): 29-34.

http://journal11.magtechjournal.com/cjcnn/CN/Y2023/V23/I1/29

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