癫痫发作后全面性脑电抑制作为癫痫猝死脑电图标志物研究进展

doi:10.3969/j.issn.1672-6731.2022.11.013

摘要/Abstract

摘要： 目前尚缺乏可靠的癫痫猝死（SUDEP）预测指标，给癫痫患者的生命安全造成巨大威胁。随着研究深入，癫痫发作特别是全面性强直-阵挛发作后，脑电图可监测到癫痫发作后全面性脑电抑制（PGES），自此PGES作为SUDEP可能的脑电图标志物备受关注。本文拟对PGES病理生理学机制、相关因素及最新研究进展进行综述，分析PGES的产生及其与SUDEP的关联性。

关键词: 癫痫, 猝死, 脑电抑制（非MeSH词）, 脑电描记术, 综述

Abstract: At present, there is a lack of reliable prediction index for sudden unexpected death in epilepsy (SUDEP), which poses a great threat to the lives of patients with epilepsy. With the deepening of research, it has been found that postictal generalized electroencephalography suppression (PGES) occurs in EEG monitoring after seizure, especially generalized tonic-clonic seizure (GTCS). Since then, PGES has attracted much attention as a possible EEG marker of SUDEP. Combined with the study of the pathophysiological mechanism, related factors of PGES phenomenon, and this paper further analyzes the relationship between the occurrence of PGES and SUDEP.

Key words: Epilepsy, Death, sudden, Electroencephalography suppression (not in MeSH), Electroencephalography, Review

陈梅, 王后芬, 史梦婷, 于云莉. 癫痫发作后全面性脑电抑制作为癫痫猝死脑电图标志物研究进展[J]. 中国现代神经疾病杂志, 2022, 22(11): 1000-1004.

CHEN Mei, WANG Hou-fen, SHI Meng-ting, YU Yun-li. Research progress of generalized electroencephalography suppression after epileptic seizure as an electroencephalography marker of sudden unexpected death in epilepsy[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2022, 22(11): 1000-1004.

http://journal11.magtechjournal.com/cjcnn/CN/Y2022/V22/I11/1000

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2 癫痫发作后全面性脑电抑制作为癫痫猝死脑电图标志物研究进展

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2 癫痫发作后全面性脑电抑制作为癫痫猝死脑电图标志物研究进展

Research progress of generalized electroencephalography suppression after epileptic seizure as an electroencephalography marker of sudden unexpected death in epilepsy

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