摘要： 偏头痛是临床最常见的原发性头痛之一，其发病机制尚未阐明。偏头痛发作可能是对脑能量代谢和氧化应激失衡的反应，提示偏头痛可能是线粒体功能障碍相关性脑代谢性疾病。本文以偏头痛触发和缓解因素、生物学标志物、遗传学研究证据和循证治疗证据为切入点，探讨偏头痛脑能量代谢机制及其与其他发病机制的关联性，以为偏头痛的预防与治疗提供新的策略，推动偏头痛个体化和精准治疗的发展。

关键词: 偏头痛, 能量代谢, 线粒体, 降钙素基因相关肽, 综述

Abstract: Migraine is one of the most common primary headaches, but its pathogenesis remains unclear. Recent studies have found that the onset of migraine may be a response to the imbalance of brain energy metabolism and oxidative stress, suggesting that migraine may be a metabolic disease of brain related to mitochondrial dysfunction. This study uses the migraine trigger and mitigating factors, biological markers, genetic research and evidence-based treatment as the breakthrough point, to explore the pathogenesis of migraine brain energy metabolism, and explores the mechanism of brain energy metabolism and other associated with migraine mechanism, in order to provide a new strategy for the treatment of migraine and promote the development of the individual and precise treatment of migraine.

Key words: Migraine, Energy metabolism, Mitochondria, Calcitonin gene-related peptide, Review