脑深部电刺激术治疗Meige综合征抑郁和睡眠障碍非运动症状初探

doi:10.3969/j.issn.1672-6731.2020.12.008

摘要/Abstract

摘要：

目的总结Meige综合征抑郁和睡眠障碍等非运动症状特点，初步探讨脑深部电刺激术对非运动症状的有效性。方法采用脑深部电刺激术治疗2019年2-5月确诊的Meige综合征患者共计12例，分别于术前和术后3、6、12个月随访时评价抑郁[抑郁自评量表（SDS）]和睡眠障碍[匹兹堡睡眠质量指数（PQSI）]严重程度。结果术前共计9/12例患者存在不同程度抑郁和睡眠障碍，术后3、6和12个月随访时，抑郁和睡眠障碍比例分别为8/12和9/12例、8/12和9/12例、6/12和10/12例，手术前后抑郁（χ²=3.102，P=0.376）和睡眠障碍（χ²=2.598，P=0.458）发生率差异无统计学意义。结论 Meige综合征患者普遍存在抑郁和睡眠障碍，脑深部电刺激术对其非运动症状无明显改善作用。

关键词: Meige综合征, 抑郁, 入睡和睡眠障碍, 深部脑刺激法

Abstract:

Objective To summarize the characteristics of non-motor symptoms of Meige's syndrome(MS), including depression and sleep disorders, and to explore the effect of deep brain stimulation (DBS) on these non-motor symptoms. Methods Twelve patients with MS treated with DBS were recruited from February to May 2019 in Department of Neurosurgery in Peking University People's Hospital. The Self-Rating Depression Scale (SDS) and Pittsburgh Sleep Quality Index (PQSI) were used to assess the depression and sleep disorders before surgery and 3, 6 and 12 months after surgery. Results Before surgery, 9 (9/12) patients had different degrees of depression and sleep disorders. At 3 months after surgery, 8 (8/12) patients had different degrees of depression and 9 (9/12) had different degrees of sleep disorders. At 6 months after surgery, 8 (8/12) patients had different degrees of depression and 9 (9/12) had different degrees of sleep disorders. At 12 months after surgery, 6 (6/12) patients had different degrees of depression and 10 (10/12) had different degrees of sleep disorders. There was no significant difference in the proportion of depression (χ²=3.102, P=0.376) and sleep disorders (χ²=2.598, P=0.458) before and after DBS. Conclusions Depression and sleep disorders are common in patients with MS, and there is no significant improvement after DBS.

Key words: Meige syndrome, Depression, Sleep initiation and maintenance disorders, Deep brain stimulation

郝庆沛, 丁虎, 刘如恩. 脑深部电刺激术治疗Meige综合征抑郁和睡眠障碍非运动症状初探[J]. 中国现代神经疾病杂志, 2020, 20(12): 1072-1075.

HAO Qing-pei, DING Hu, LIU Ru-en. Deep brain stimulation for non-motor symptoms of depression and sleep disorders in Meige's syndrome[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2020, 20(12): 1072-1075.

http://journal11.magtechjournal.com/cjcnn/CN/Y2020/V20/I12/1072

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