脑库与神经病学建设

doi:10.3969/j.issn.1672-6731.2020.10.012

中国现代神经疾病杂志 ›› 2020, Vol. 20 ›› Issue (10): 914-923. doi: 10.3969/j.issn.1672-6731.2020.10.012

2 脑库与神经病学建设

曹凌晓¹, 黄越¹, 蔡志友², 陈彪³, 陈生弟⁴, 樊东升⁵, 方伯言⁶, 郭燕军⁷, 韩璎³, 黄华品⁸, 纪文军⁹, 李红燕¹⁰, 刘坤¹¹, 裴中¹², 彭丹涛¹³, 施福东¹⁴, 隋轶¹⁵, 唐北沙¹⁶, 王枫¹⁷, 王雯¹⁸, 王朝霞¹⁹, 吴安华²⁰, 徐运²¹, 杨东东²², 张国富²³, 张力伟¹, 张振涛²⁴, 赵伟²⁵, 赵性泉¹, 王拥军¹

1 100070 首都医科大学附属北京天坛医院神经病学中心国家神经系统疾病临床医学研究中心;
2 400013 中国科学院大学重庆医院重庆市人民医院神经内科;
3 100053 北京, 首都医科大学宣武医院神经内科国家老年医学临床研究中心;
4 200025 上海交通大学医学院附属瑞金医院神经科;
5 100191 北京大学第三医院神经内科;
6 100144 首都医科大学附属北京康复医院神经内科;
7 100730 首都医科大学附属北京同仁医院神经内科;
8 350001 福州, 福建医科大学附属协和医院神经内科;
9 719000 陕西省榆林市第二医院神经外科;
10 830000 乌鲁木齐, 新疆维吾尔自治区人民医院神经内科;
11 410007 长沙, 湖南省第二人民医院湖南省脑科医院神经外科;
12 510080 广州, 中山大学附属第一医院神经科;
13 100029 北京, 中日友好医院神经内科;
14 300052 天津医科大学总医院神经内科;
15 110041 辽宁省沈阳市第一人民医院神经内科;
16 410008 长沙, 中南大学湘雅医院神经内科国家老年疾病临床医学研究中心;
17 214023 江苏省无锡市人民医院神经内科;
18 006100 河北省沧州中西医结合医院脑病科;
19 100034 北京大学第一医院神经内科;
20 110001 沈阳, 中国医科大学附属第一医院神经外科;
21 210008 南京大学医学院附属鼓楼医院神经内科;
22 610072 成都中医药大学附属医院神经内科;
23 100088首都医科大学附属北京安定医院精神科国家神经精神临床医学研究中心;
24 430060 武汉大学人民医院神经内科;
25 072151 河北省保定市满城区人民医院神经内科

收稿日期:2020-10-13 出版日期:2020-10-25 发布日期:2020-10-30
通讯作者: 黄越,Email:yue.huang@ncrcnd.org.cn;王拥军,Email:yongjunwang111@aliyun.com
基金资助:
国家自然科学基金资助项目（项目编号：82071417）；国家发改委疑难病症诊治能力提升工程项目

Brain bank in neurology history and development

CAO Ling-xiao¹, HUANG Yue¹, CAI Zhi-you², CHAN Piu³, CHEN Sheng-di⁴, FAN Dong-sheng⁵, FANG Bo-yan⁶, GUO Yan-jun⁷, HAN Ying³, HUANG Hua-pin⁸, JI Wen-jun⁹, LI Hong-yan¹⁰, LIU Kun¹¹, PEI Zhong¹², PENG Dan-tao¹³, SHI Fu-dong¹⁴, SUI Yi¹⁵, TANG Bei-sha¹⁶, WANG Feng¹⁷, WANG Wen¹⁸, WANG Zhao-xia¹⁹, WU An-hua²⁰, XU Yun²¹, YANG Dong-dong²², ZHANG Guo-fu²³, ZHANG Li-wei¹, ZHANG Zhen-tao²⁴, ZHAO Wei²⁵, ZHAO Xing-quan¹, WANG Yong-jun¹

1 Center of Neurology, Beijing Tiantan Hospital, Capital Medical University;National Clinical Research Center for Neurological Diseases, Beijing 100070, China;
2 Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400013, China;
3 Department of Neurology, Beijing Xuanwu Hospital, Capital Medical University;National Center for Geriatrics Clinical Medicine Research, Beijing 100053, China;
4 Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China;
5 Department of Neurology, Peking University Third Hospital, Beijing 100191, China;
6 Department of Neurology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100144, China;
7 Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;
8 Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China;
9 Department of Neurosurgery, Yulin Second Hospital, Yulin 719000, Shaanxi, China;
10 Department of Neurology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, Xinjiang, China;
11 Department of Neurosurgery, The Second People's Hospital of Hu'nan Province;Brain Hospital of Hu'nan Province, Changsha 410007, Hu'nan, China;
12 Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China;
13 Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China;
14 Department of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, China;
15 Department of Neurology, The First People's Hospital of Shenyang, Shenyang 110041, Liaoning, China;
16 Department of Neurology, Xiangya Hospital, Central South University;National Center for Geriatrics Clinical Medicine Research, Changsha 410008, Hu'nan, China;
17 Department of Neurology, Wuxi People's Hospital, Wuxi 214023, Jiangsu, China;
18 Department of Neurology, Cangzhou Hospital of Integrated TCM-WM, Cangzhou 006100, Hebei, China;
19 Department of Neurology, Peking University First Hospital, Beijing 100034, China;
20 Department of Neurosurgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China;
21 Department of Neurology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China;
22 Department of Neurology, Affiliated Hospital of Chengdu Traditional Chinese Medicine University, Chengdu 610072, Sichuan, China;
23 Department of Psychology, Beijing Anding Hospital, Capital Medical University;National Mental and Mental Disease Clinical Medicine Research Center, Beijing 100088, China;
24 Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China;
25 Department of Neurology, Mancheng People's Hospital, Baoding 072151, Hebei, China

Received:2020-10-13 Online:2020-10-25 Published:2020-10-30
Supported by:
This study was supported by the National Natural Science Foundation of China (No. 82071417) and Program of Advancing Rare and Refractory Disorders from National Development & Reform Council.

摘要/Abstract

摘要：

人脑组织库（简称脑库）是通过遗体器官组织捐献渠道进行的脑组织采集、存储、研究并资源共享，为医学研究者开展神经病学和神经科学研究而奠定基础的机构。脑库的发展伴随神经病学发展的始终：神经病学始于对个案脑组织的尸体解剖病理学检查，随着脑库建设可将神经病学再度带入崭新的认知领域，促进神经系统疾病新病种的发现与确定，对探索疾病的发生发展机制和新的治疗手段具有重要作用。本文拟从脑库发展史、国内外发展现状及其与神经病学的时代意义等方面进行阐述，并探讨我国脑库建设的机遇与挑战。

关键词: 脑, 神经病学, 神经科学, 病理学, 综述

Abstract:

Human brain bank is the foundation for neurology and neuroscience, which provides research materials for medical scientists to explore what happen in human brains. Through voluntary postmortem brain tissue donation, brain bank collects, classifies, stores and distributes brain tissue samples for researchers with appropriate research proposals, so as to facilitate researchers to conduct human brain research. History showed that the act of brain only autopsy distinguished neurology as a distinct discipline. The emerges of brain banking accompanied with the advances of neurology and neuroscience. It facilitates the development of neurology from neuropathological examination feedback about the clinical presentations of the brain donor, plays an important role in the definition of novel neurological diseases, and also makes an extraordinary contribution to the disease mechanisms and novel therapeutic discoveries. This manuscript elaborated the history, current situation, and the impacts of human brain banking on current neurology. Furthermore, we discussed about the opportunities and challenges of brain banking in China.

Key words: Brain, Neurology, Neurosciences, Pathology, Review

曹凌晓, 黄越, 蔡志友, 陈彪, 陈生弟, 樊东升, 方伯言, 郭燕军, 韩璎, 黄华品, 纪文军, 李红燕, 刘坤, 裴中, 彭丹涛, 施福东, 隋轶, 唐北沙, 王枫, 王雯, 王朝霞, 吴安华, 徐运, 杨东东, 张国富, 张力伟, 张振涛, 赵伟, 赵性泉, 王拥军. 脑库与神经病学建设[J]. 中国现代神经疾病杂志, 2020, 20(10): 914-923.

CAO Ling-xiao, HUANG Yue, CAI Zhi-you, CHAN Piu, CHEN Sheng-di, FAN Dong-sheng, FANG Bo-yan, GUO Yan-jun, HAN Ying, HUANG Hua-pin, JI Wen-jun, LI Hong-yan, LIU Kun, PEI Zhong, PENG Dan-tao, SHI Fu-dong, SUI Yi, TANG Bei-sha, WANG Feng, WANG Wen, WANG Zhao-xia, WU An-hua, XU Yun, YANG Dong-dong, ZHANG Guo-fu, ZHANG Li-wei, ZHANG Zhen-tao, ZHAO Wei, ZHAO Xing-quan, WANG Yong-jun. Brain bank in neurology history and development[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2020, 20(10): 914-923.

http://journal11.magtechjournal.com/cjcnn/CN/Y2020/V20/I10/914

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