中国现代神经疾病杂志 ›› 2020, Vol. 20 ›› Issue (4): 270-276. doi: 10.3969/j.issn.1672-6731.2020.04.005

• 专题综述 • 上一篇    下一篇

2 儿童H3 K27M突变型弥漫性中线胶质瘤治疗进展

罗敏捷, 陈嘉志, 张旺明   

  1. 510280 广州, 南方医科大学珠江医院小儿神经外科
  • 收稿日期:2020-04-13 出版日期:2020-04-25 发布日期:2020-04-24
  • 通讯作者: 张旺明,Email:wzhang@vip.126.com

Progress in the treatment of pediatric H3 K27M mutant diffuse midline glioma

LUO Min-jie, CHEN Jia-zhi, ZHANG Wang-ming   

  1. Department of Pediatric Neurosurgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, Guangdong, China
  • Received:2020-04-13 Online:2020-04-25 Published:2020-04-24

摘要:

H3 K27M突变型弥漫性中线胶质瘤是好发于儿童的高级别胶质瘤,恶性程度高、预后极差,中位生存期不足1年,目前尚无标准治疗方案,手术切除和常规放化疗难以改善预后。随着近年立体定向肿瘤组织活检术的开展,肿瘤组织独特的生物学特性逐渐得到澄清,新的靶向治疗方法如靶向化疗、对流增强给药、表观遗传学治疗、嵌合抗原受体T细胞治疗逐渐应用于临床试验。本文拟综述H3 K27M突变型弥漫性中线胶质瘤相关最新治疗研究进展并探讨下一步治疗目标。

关键词: 神经胶质瘤, 组蛋白类, 儿童, 基因, 突变, 化放疗, 综述

Abstract:

The high-grade glioma, H3 K27M mutant diffuse midline glioma tends to occur in children, and its high malignancy lead to very poor prognosis after treatment (median survival after diagnosis <1 year). At present, there is no standard treatment for pediatric diffuse midline glioma; surgery, conventional radiotherapy and chemotherapy are difficult to improve the prognosis. In recent years, the benefit from the stereotactic biopsy, the unique biological characteristics of pediatric H3 K27M mutant diffuse midline are being clarified. New targeted treatment methods, such as targeted chemotherapy, convection-enhanced delivery, epigenetic therapy, and chimeric antigen receptor T-cell therapy are gradually being included in the scope of clinical research. In order to clarify the current treatment progress and discuss the future goals, this article reviews recent studies about the treatment to pediatric H3 K27M mutant diffuse midline glioma.

Key words: Glioma, Histones, Child, Genes, Mutation, Chemoradiotherapy, Review