中国现代神经疾病杂志 ›› 2020, Vol. 20 ›› Issue (4): 263-269. doi: 10.3969/j.issn.1672-6731.2020.04.004

• 专题综述 • 上一篇    下一篇

2 颅内生殖细胞肿瘤标志物研究进展

韩磊, 何子俊, 方陆雄, 宋烨   

  1. 510515 广州, 南方医科大学南方医院神经外科
  • 收稿日期:2020-04-05 出版日期:2020-04-25 发布日期:2020-04-24
  • 通讯作者: 宋烨,Email:songye0724@126.com
  • 基金资助:

    2019年广东省广州市科技计划项目(项目编号:201903010048)

Advances in the study of tumor markers for intracranial germ cell tumors

HAN Lei, HE Zi-jun, FANG Lu-xiong, SONG Ye   

  1. Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
  • Received:2020-04-05 Online:2020-04-25 Published:2020-04-24
  • Supported by:

    This study was supported by the Science and Technology Program of Guangzhou, Guangdong Province, China (No. 201903010048).

摘要:

颅内生殖细胞肿瘤是一类好发于儿童和青少年的高异质性肿瘤,其诊断与治疗策略与组织分型密切相关,由于外科手术适应证范围较小,使组织病理学标本的获取受到限制,加之活检困难或不全面等问题,给临床诊疗带来一定困难。而具有特异性的肿瘤标志物对颅内生殖细胞肿瘤的辅助诊断、治疗方案制定、预后评估均具有重要意义。本文拟就经典的组织学标志物、血清和(或)脑脊液肿瘤标志物等的研究进展进行综述,以为临床与科研提供参考。

关键词: 肿瘤, 生殖细胞和胚胎性, 脑肿瘤, 生物标记, 肿瘤, 综述

Abstract:

Intracranial germ cell tumors (ICGCTs) are highly heterogeneous tumors that tend to occur in children and adolescents, and their diagnosis and treatment strategies are closely related to their pathological components. However, due to their low surgical treatment rate, limited access to pathological specimens of tumors, and difficult or incomplete pathological biopsy, it is difficult to make clinical diagnosis and treatment. Specific tumor markers play an important role in the auxiliary diagnosis, treatment and prognosis prediction of ICGCTs. This paper intends to review the studies on classical histological markers, serology and/or cerebrospinal fluid tumor markers of ICGCTs, so as to provide references for clinical application and research.

Key words: Neoplasms, germ cell and embryonal, Brain neoplasms, Biomarkers, tumor, Review