摘要：

目的 通过循证医学方法分析脑卒中后疲劳相关危险因素。方法 分别以 post-stroke fatigue、PSF、factor、prevalence、risk factor 等英文词汇作为检索词，检索美国国立医学图书馆生物医学信息检索系统（PubMed）、荷兰医学文摘（EMBASE/SCOPUS）、英国 Cochrane 图书馆等数据库中关于脑卒中后疲劳危险因素的随机对照试验、病例对照研究、队列研究和回顾性病例系列研究结果；采用Jadad量表和 Stata 12.0 统计软件进行文献质量评价和 Meta 分析。结果 共获得6986篇文献，经剔除重复和不符合纳入标准者，最终获得 23 项临床研究计 9135 例脑卒中后疲劳患者。分析显示，脑卒中前疲劳（OR = 4.790，95%CI：0.790 ~ 29.160；P = 0.000）、抑郁（OR = 3.530，95%CI：2.580 ~ 4.850；P = 0.000）、焦虑（OR = 1.200，95%CI：1.070 ~ 1.350；P = 0.041）是脑卒中后疲劳的危险因素。结论 脑卒中前疲劳、抑郁、焦虑是脑卒中后疲劳的危险因素，临床医师应重视相关危险因素，早期预防并治疗，提高脑卒中患者的生活质量。

关键词: 卒中, 疲劳, 危险因素, Meta分析

Abstract:

Objective Evidence-based medicine was used to analyze the risk factors associated with post-stroke fatigue (PSF). Methods Words such as post-stroke fatigue, PSF, factor, prevalence, risk factor were used as search terms. Computer searches were performed by PubMed, EMBASE/SCOPUS and Cochrane Library. Databases were used to search for randomized controlled trials, case-control studies, cohort studies and retrospective case series on PSF risk factors. The Jadad Scale and Stata 12.0 statistical software were used for literature quality assessment and Meta-analysis. Results A total of 6986 articles were obtained. After eliminating duplicates and non-compliance criteria, a total of 9135 patients with PSF were included in 23 clinical studies. Meta-analysis showed pre-stroke fatigue (OR = 4.790, 95% CI: 0.790-29.160; P = 0.000), depression (OR = 3.530, 95%CI: 2.580-4.850; P = 0.000), anxiety (OR = 1.200, 95%CI: 1.070-1.350; P = 0.041) are risk factors for PSF. Conclusions Pre-stroke fatigue, depression and anxiety are risk factors for PSF. Clinicians should pay attention to relevant risk factors, early preventionand treatment, and improve the quality of life of patients with stroke.

Key words: Stroke, Fatigue, Risk factors, Meta-analysis