摘要：

发作间期局限性PET高代谢在临床实践中常对致痫灶的定位造成困扰，因此正确解读其临床意义具有重要价值。通过文献回顾，对发作间期PET高代谢信号的可能机制如频繁痫样放电、代偿性活动、兴奋性毒性作用等进行分析，并对一些特定癫痫综合征或疾病发作间期局限性PET高代谢信号的出现频率和可能机制进行综述，有助于归纳其在不同临床背景下作为术前评价指标的价值；同时提示对发作间期局限性PET高代谢信号的解读应结合病因及其他临床资料进行综合分析，以助临床实践。

关键词: 癫痫, 正电子发射断层显像术, 高代谢（非MeSH词）, 综述

Abstract:

Interictal regional positron emission tomography (PET) hypermetabolism often causes confusion in the localization of epileptogenic zone. It is of practical importance to make right interpretation. This article reviews previous literatures and analyzes possible mechanisms of interictal PET hypermetabolism, such as frequent epileptiform discharges, compensatory activities, excitotoxicity, etc. Besides, the prevalence and possible mechanisms of interictal regional PET hypermetabolism in some specific epileptic syndromes or diseases are also reviewed. This helps to summarizethe value ofinterictal PET hypermetabolism in presurgical evaluation under different clinical backgrounds, and also implies comprehensive analysis with underlying etiology and other clinical information is necessary to aid the clinicalpractice.

Key words: Epilepsy, Positron-emission tomography, Hypermetabolism (Notin MeSH), Review