摘要：

原发性失眠的神经机制研究日益受到关注，尤其是随着MRI的发展和临床应用，原发性失眠相关脑结构和功能研究越来越深入。根据过度觉醒假说，原发性失眠患者皮质和皮质下某些脑区存在结构、功能和代谢异常，这些脑区主要包括杏仁核、海马、扣带回、岛叶、额叶、顶叶。本文拟对原发性失眠神经机制的MRI研究进展进行综述。

关键词: 入睡和睡眠障碍, 磁共振成像, 综述

Abstract:

In recent years, more and more researches focused on the neural mechanism of primary insomnia (PI), especially with the development and application of MRI, and researches of brain structure and function related with primary insomnia were more and more in-depth. According to the hyperarousal hypothesis, there are abnormal structure, function and metabolism under certain brain regions of the cortex and subcortex of primary insomnia patients, including amygdala, hippocampus, cingulate gyrus, insular lobe, frontal lobe and parietal lobe. This paper reviewed the research progress of neural mechanisms of primary insomnia by using MRI.

Key words: Sleep initiation and maintenance disorders, Magnetic resonance imaging, Review