摘要：

胶质瘤在脑实质内呈弥漫性浸润生长，即使遵循“最大限度安全切除”的治疗原则，残留肿瘤细胞仍对辅助放射治疗和药物化疗抵抗并继续在脑组织内侵袭迁移，是胶质瘤复发及其在中枢神经系统播散的主要根源，因此，调控胶质瘤侵袭迁移为胶质瘤的治疗提供新的方法。本文拟就我国国民经济和社会发展第十二个五年规划（简称“十二五”）时期，天津医科大学总医院杨学军教授研究团体在胶质瘤侵袭迁移研究方面取得的成果进行简要综述。

关键词: 神经胶质瘤, 肿瘤侵润, 生物学, 中国, 综述

Abstract:

Glioma shows diffuse infiltrative growth in the brain parenchyma. Even following the principle of "maximum safe resection", the residual tumor cells are resistant to adjuvant chemoradiotherapy and continue to invase and migrate in the brain tissue. This is the main reason for the recurrence of glioma and the dissemination in the central nervous system (CNS). As a result, understanding the mode of glioma invasion and migration can provide a new method for the treatment of glioma. This paper reviews our research findings of the invasion and migration of glioma during the period of Twelfth Five-Year Plan for National Economic and Social Development.

Key words: Glioma, Neoplasm invasiveness, Biology, China, Review