中国现代神经疾病杂志 ›› 2017, Vol. 17 ›› Issue (6): 403-408. doi: 10.3969/j.issn.1672-6731.2017.06.003

• 专题综述 • 上一篇    下一篇

2 帕金森病康复治疗及其作用机制研究进展

刘瑾, 杨新新, 项洁   

  1. 221004 徐州医科大学研究生学院2014 级(刘瑾)
    221002 徐州医科大学附属医院神经内科(杨新新),康复科(项洁)
  • 出版日期:2017-06-25 发布日期:2017-07-21
  • 通讯作者: 项洁(Email:xj1111@163.com)
  • 基金资助:

    国家自然科学基金资助项目(项目编号:81671269);江苏省“六大人才高峰”资助项目(项目编号:2015-WSN-064)

Research progress of rehabilitation therapy in Parkinson's disease and its mechanism

LIU Jin1, YANG Xin-xin2, XIANG Jie3   

  1. 1Grade 2014, Graduate School, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China
    2Department of Neurology, 3Department of Rehabilitation, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu, China
  • Online:2017-06-25 Published:2017-07-21
  • Contact: XIANG Jie(Email:xj1111@163.com)
  • Supported by:

    This study was supported by the National Natural Science Foundation of China (No. 81671269) and "Six Peaks of Talents" Support Program of Jiangsu Province, China (No. 2015-WSN-064).

摘要:

帕金森病是渐进性黑质致密部多巴胺能神经元退行性变导致的疾病,康复治疗可以延缓病情进展,改善运动症状和非运动症状,提高患者日常生活活动能力。康复训练改善帕金森病症状的机制复杂,涉及多种分子学机制,本文系统阐述康复训练对帕金森病症状的改善作用,以及神经递质、营养因子、突触可塑性和免疫系统等方面的分子学机制。

关键词: 帕金森病, 康复, 综述

Abstract:

Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra pars compacta. Rehabilitation therapy can delay the development of disease, improve motor symptoms and non - motor symptoms (NMS), and consequently improve the activities of daily living (ADL) in patients with PD. The mechanism of rehabilitation improving the symptoms of PD is very complex, involving a variety of molecular mechanisms. Thus, this review will focus on the effect of rehabilitation therapy on PD and the underlying molecular mechanism including neurotransmitters, trophic factors, synaptic plasticity and immune system.

Key words: Parkinson disease, Rehabilitation, Review