摘要：
目的 探讨腔隙性梗死后血管性认知损害的相关危险因素。方法 共138 例腔隙性梗死患者根据蒙特利尔认知评价量表分为认知功能正常55例、轻度认知功能障碍73例和重度认知功能障碍10 例，采用单因素和多因素后退法Logistic 回归分析筛查腔隙性梗死后血管性认知损害相关危险因素。结果 关键部位梗死灶（OR = 1.179，95%CI：0.870 ~ 2.472；P = 0.012）和脑白质高信号3 ~ 4 级（OR =2.005，95%CI：0.910 ~ 4.502；P = 0.024）是腔隙性梗死患者出现血管性认知损害的独立危险因素。结论 腔隙性梗死后血管性认知损害是多因素共同作用的结果，其中关键部位梗死灶和脑白质高信号3 ~4级是独立危险因素。
关键词:
脑梗死,
认知障碍,
危险因素,
回归分析
Abstract:
Objective To study the risk factors for vascular cognitive impairment (VCI) after lacunar infarct (LACI). Methods A total of 138 patients with LACI were evaluated by Montreal Cognitive Assessment (MoCA), and divided into normal cognitive function group (normal, N = 55), mild cognitive impairment (MCI) group (mild, N = 73) and severe cognitive impairment group (severe, N = 10). Univariate and backward multivariate Logistic regression analysis were used to screen the risk factors for VCI after LACI. Results Logistic regression analysis showed that infarct in critical site (OR = 1.179, 95% CI: 0.870-2.472; P = 0.012) and white matter hyperintensity (WMH) Grade 3-4 (OR = 2.005, 95% CI: 0.910-4.502; P = 0.024) were independent risk factors for VCI in patients with LACI. Conclusions VCI in patients with LACI is related to multiple factors, in which infarct in critical site and WMH Grade 3-4 are independent risk factors.
Key words:
蒋晗, 曾倩, 宋春江, 吴波. 腔隙性梗死患者轻度血管性认知损害危险因素分析[J]. 中国现代神经疾病杂志, 2016, 16(11): 774-778.
JIANG Han, ZENG Qian, SONG Chun-jiang, WU Bo. A study on risk factors for mild vascular cognitive impairment in patients with lacunar infarct[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2016, 16(11): 774-778.