摘要：

概述细胞过继免疫疗法治疗恶性胶质瘤过程中淋巴因子激活的杀伤细胞、自然杀伤细胞、γδT 细胞、肿瘤浸润淋巴细胞、抗原特异性细胞毒性T 细胞、CD4⁺T 细胞等效应细胞的作用，以及各种效应细胞特性、优缺点，以及目前研究趋势和进展。

关键词: 神经胶质瘤, 免疫疗法, 过继, 综述

Abstract:

Malignant glioma is the most common malignant tumor of central nervous system (CNS). Surgery is the main treatment method, supplemented by radiation and chemotherapy. But the problems of too much trauma, easy recurrence and poor prognosis cannot be avoided. Because of strong anti-tumor specificity, mild adverse reaction and long-term memory etc, immune therapy may be the best auxiliary treatment, and even can replace the surgical treatment. This article focused on the role of engineering cells, including lymphokine-activated killer cell (LAK), natural killer cell (NK), γδ T cell, tumor infiltrating lymphocyte cell (TIL), cytotoxic T lymphocyte cell (CTL) and CD4⁺ T cell, in the process of treating malignant glioma by adoptive cell therapy (ACT) and reviewed the characteristics, advantage and disadvantages, research trends and progress of these cells.

Key words: Glioma, Immunotherapy, adoptive, Review