摘要： 目的 观察黄连素联合阿托伐他汀对急性缺血性卒中患者血清超敏C-反应蛋白和脂肪细胞型脂肪酸结合蛋白表达水平的影响，评价其临床疗效。方法 55 例急性缺血性卒中患者随机分为阿托伐他汀20 mg/d 组、阿托伐他汀40 mg/d 组和黄连素0.40 g（3 次/d）+ 阿托伐他汀20 mg/d 组（联合治疗组），治疗3 个月后比较血清超敏C-反应蛋白和脂肪细胞型脂肪酸结合蛋白表达变化。结果 治疗前后3 组患者血清超敏C-反应蛋白和脂肪细胞型脂肪酸结合蛋白表达水平差异均有统计学意义（P = 0.023，0.000）；治疗后3 个月时，3 组患者血清超敏C-反应蛋白和脂肪细胞型脂肪酸结合蛋白表达水平不同程度下降，分别为（1.69 ± 2.29）和（281.43 ± 311.05）mg/L、（7.81 ± 12.48）和（321.59 ± 289.35）mg/L、（2.16 ± 3.34）和（376.55 ± 249.72）mg/L，但组间差异未达到统计学意义（均P > 0.05），而且治疗药物与观察时间点之间不存在交互作用（均P > 0.05）。结论 黄连素联合阿托伐他汀降低急性缺血性卒中患者血清炎症反应标志物超敏C-反应蛋白和脂肪细胞型脂肪酸结合蛋白表达水平的作用与阿托伐他汀强化治疗（40 mg/d）相似。
关键词:
脑缺血,
小檗碱,
降血脂药,
C 反应蛋白质,
脂肪酸结合蛋白质类
Abstract: Objective To observe the influence of berberine combining with atorvastatin on serum high-sensitivity C-reactive protein (hs-CRP) and adipocyte fatty acid-binding protein (A-FABP) in patients with acute ischemic stroke. Methods Ischemic stroke patients (N = 55) were randomized into 3 groups: atorvastatin 20 mg/d (N = 28), atorvastatin 40 mg/d (N = 11) and berberine 0.40 g three times a day + atorvastatin 20 mg/d (combined treatment, N = 16). They were treated for 3 months. The expression changes of serum hs-CRP and A-FABP before and after treatment were compared among 3 groups. Results There were significant decreases between before and 3 months after treatment on the expression of hs-CRP and A-FABP in 3 groups (P = 0.023, 0.000). After treatment, both the expression of hs-CRP and A-FABP significantly decreased, and the decreases were (1.69 ± 2.29) and (281.43 ± 311.05) mg/L in atorvastatin 20 mg/d group, (7.81 ± 12.48) and (321.59 ± 289.35) mg/L in atorvastatin 40 mg/d group, and (2.16 ± 3.34) and (376.55 ± 249.72) mg/L in combined treatment group. However, there was no significant difference among 3 groups (P > 0.05, for all), and there was no correlation between drugs and observation time points (P > 0.05, for all). Conclusions The effect of berberine combined with atorvastatin on hs-CRP and A-FABP is similar to atorvastation (40 mg/d) therapy.
Key words:
Brain ischemia,
Berberine,
Antilipemic agents,
C-reactive protein,
Fatty acid-binding proteins
朱飞奇, 陈略, 朱瑾华. 黄连素联合阿托伐他汀对急性缺血性卒中患者血清超敏C-反应蛋白和脂肪细胞型脂肪酸结合蛋白水平的影响[J]. 中国现代神经疾病杂志, 2015, 15(1): 43-47.
ZHU Fei-qi, CHEN Lüe, ZHU Jin-hua. Influence of berberine combining with atorvastatin on serum high-sensitivity C-reactive protein and adipocyte fatty acid-binding protein in patients with acute ischemic stroke[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2015, 15(1): 43-47.