国家自然科学基金?广东省联合基金重点资助项目（项目编号：U1032004）；国家自然科学基金资助项目（项目编号：30870851）；国家自然科学基金资助项目（项目编号：81271401）；国家科技支撑计划项目（项目编号：2012BAI09B04）；国家科技重大专项课题?重大新药创制（项目编号：2011ZX09307-001）；广东省科技计划项目（项目编号：2011A030400006）；广东省人口和计划生育委员会科技项目（项目编号：2009208）；广东省人口和计划生育委员会重点项目（项目编号：2010102）

This study was supported by Joint Fund of National Natural Science Foundation of China and Natural Science Foundation of Guangdong Province of China (No. U1032004), National Natural Science Foundation of China (No. 30870851, 81271401), Supporting Program for Science and Technology Research of China (No. 2012BAI09B04), Major New Drugs Innovation and Development of Important National Science & Technology Specific Projects (No. 2011ZX09307-001), Technology Plan Project of Guangdong Province (No. 2011A030400006), Science and Technology Project of Population and Family Planning Commission of Guangdong Province (No. 2009208), and Key Project of Population and Family Planning Commission of Guangdong Province (No. 2010102).