摘要： 不宁腿综合征为临床常见中枢神经系统感觉运动障碍性疾病，发病机制尚不明确，与遗传因素或多巴胺能系统功能失调有关。发病原因与缺铁性贫血、妊娠、免疫系统疾病、肾衰竭、糖尿病、周围神经病等有关。临床主要表现为感觉障碍、运动症状，并于休息时、傍晚或夜间出现或加重。以铁离子、多巴胺制剂、多巴胺受体激动药、抗癫痫药及阿片类药物为主要治疗药物。

关键词: 不宁腿综合征, 睡眠障碍, 综述

Abstract: Restless legs syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs especially at rest. Symptoms worsen in the evening and night and improve with activity such as walking. RLS may be secondary to, or exacerbated by, a number of conditions that include iron deficiency, pregnancy, end stage renal disease, diabetes and rheumatoid arthritis, or with neurological disorders such as peripheral neuropathy. Treatments for RLS include: dopaminergic agents, dopamine receptor agonists, opioids, sedative hypnotics, anticonvulsants, clonidine, minerals and vitamins et al.

Key words: Restless legs syndrome, Sleep disorders, Review