Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (3): 514-518.doi: 10.16352/j.issn.1001-6325.2023.03.514

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Research progress on the role of DNA methylation in the occurrence and prognosis of lung cancer

XUE Jianchao1, WANG Yadong1, LI Bowen1, LIU Xinyu2, LIANG Naixin1*, LI Shanqing1   

  1. 1. Department of Thoracic Surgery, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730;
    2. Grade 2016, Eight-year Program of Clinical Medicine, PUMC, Beijing 100730, China
  • Received:2021-10-25 Revised:2022-05-07 Online:2023-03-05 Published:2023-02-27
  • Contact: *

Abstract: Lung cancer is a leading cause of cancer-related morbidity and mortality in China. Early recurrence is the main cause of poor prognosis. The existing prognostic indicators are insufficient. Thus, it is urgent to find reliable prognostic indicators. DNA methylation is the most important epigenetic change in the development of lung cancer. With the development of high-throughput sequencing technology, DNA methylation has shown its great clinical value in the prognosis prediction of lung cancer patients due to its stable and detectable features.

Key words: lung cancer, DNA methylation, prognosis, epigenetics

CLC Number: