Basic & Clinical Medicine ›› 2017, Vol. 37 ›› Issue (3): 415-418.

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Controversy of soluble urokinase-type plasminogen activator receptor in gastrointestinal cancer


  • Received:2016-03-28 Revised:2016-05-31 Online:2017-03-05 Published:2017-02-23

Abstract: Soluble urokinase- type plasminogen activator receptor (suPAR) is the soluble form of urokinase- type plasminogen activator receptor (uPAR). Besides being a new biomarker of inflammation, suPAR plays an important role in the growth, development, invasion and metastasis of gastrointestinal cancer. Recent research suggests that suPAR has significant value in the molecular diagnosis of incipient tumors, monitoring of the therapeutic response and further development of the molecular targeted new agents.

Key words: suPAR, cancer, prognosis, biomarker