Abstract: The incidence of fungal infections in central nervous system (CNS) has been increased recently. Intracranial fungal infections included diffuse infections and focal infections, the clinical presentations were fever and intracranial hypertension due to meningitis, meningoencephalitis and even focal neurological deficits. The diagnosis of intracranial fungal infections depends on the history, epidemiology, underlying diseases, clinical manifestations, imaging findings and laboratory examinations, while the golden standard is the identification of the fungi in the brain tissue or cerebral spinal fluid. Controlling the underlying risks, administering effective antifungal drugs and removing fungal abscesses are the treatment principles for CNS fungal infections. New diagnostic and therapeutic approaches need to be explored to improve the prognosis of these patients.

Key words: fugal，infection，central nervous system，diagnosis，treatment