Expression of CBX7 protein in cervical cancer and its clinical significance

doi:10.16352/j.issn.1001-6325.2022.05.006

Abstract

Abstract: Objective To investigate the expression and clinical significance of chomobox homolog 7 (CBX7) in cervical cancer(CC)tissues. Methods Tissue samples of 71 patients with CC who were first diagnosed with CC and underwent cervical resection in the First Affiliated Hospital of Xinjiang Medical University from 2013 to 2020 were retrospectively collected. The expression of CBX7 was detected by immunohistochemistry(IHC). At the same time, data of clinical pathology from the patients were collected and survival analysis was conducted after following-up. Results CBX7 was highly expressed in 10 CC tissues, moderately low in 19 CC tissues, and negative in 42 CC tissues(P＜0.05). The expression of CBX7 was different and rlated to clinical stages, lymphatic metastasis and vascular invasion(P＜0.05). Compared with the negative and low CBX7 expression groups, the survival rate of CC patients with high CBX7 expression was significantly enhanced (P＜0.05)and the survival rate of patients with different CBX7 expression levels were significantly different (P＜0.05). Conclusions The negative expression of CBX7 protein in CC tissues may be associated with poor prognosis of CC patients.CBX7 expression in CC tissues is a potential prognostic fact of CC patients.

Key words: cervical cancer, expression of CBX7, prognosis, clinical significance

CLC Number:

Hatimihan· MAIMAITI, Gulikezi·MAIMAITIREXIATI, LI Yu-ting, ZHOU Chang-hui, LI Rong. Expression of CBX7 protein in cervical cancer and its clinical significance[J]. Basic & Clinical Medicine, 2022, 42(5): 721-725.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2022.05.006

http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2022/V42/I5/721

References

[1] 苏博,闫振宇,郝尚辉,等.宫颈癌患者癌组织中IL-33表达水平与临床病理特征及预后的相关性[J].实用医学杂志,2021,37:2214-2218.
[2] Musa J, Achenbach CJ, O'Dwyer LC, et al. Effect of cervical cancer education and provider recommendation for screening on screening rates: a systematic review and meta-analysis[J].PLoS One,2017,12:e0183924.doi:10.1371/journal.pone.0190661.
[3] Thaker PH, Salani R, Brady WE, et al. A phase I trial of paclitaxel, cisplatin, and veliparib in the treatment of persistent or recurrent carcinoma of the cervix: an NRG oncology study (NCT#01281852)[J].Ann Oncol,2017,28:505-511.
[4] Canfell K, Kim JJ, Brisson M, et al. Mortality impact of achieving WHO cervical cancer elimination targets: a comparative modelling analysis in 78 low-income and lower-middle-income countries[J].Lancet,2020,395:591-603.
[5] 陈茜,刘宪,崔南,等.敲除EZH2抑制人宫颈癌细胞系迁移和侵袭[J].基础医学与临床,2022,42:395-400.
[6] Ni SJ, Zhao LQ, Wang XF, et al. CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-κB-miR-21 pathways[J].J Hematol Oncol,2018,11:17.doi:10.1186/s13045018-0562-z.
[7] Ni SJ, Wang H, Zhu X, et al. CBX7 suppresses cell proliferation, migration, and invasion through the inhibition of PTEN/Akt signaling in pancreatic cancer[J].Oncotarget,2017,8:8010-8021.
[8] To KK,Tong WS,Wu WK,et al.PPAR gamma agonists sensitize PTEN-deficient lung cancer cells resistant to EGFR tyrosine kinase inhibitors[J].Eur J Pharmacol,2018.doi:10.1016/j.ejphar.2018.01.036.
[9] 刘俊雅,范姝婕,黄薇,等.Hsp90在胰腺癌组织中表达升高及其临床病理意义[J].基础医学与临床,2018,38:497-501.
[10] Gong Lf,Tang Y,Jiang L,et al. Regulation of circ GOLPH3 and its binding protein CBX7 on the proliferation and apoptosis of prostate cancer cells[J].Biosci Rep,2020,40.doi:10.1042/BSR20200936.
[11] Huang ZN,Yan YL,Zhu Z,et al. CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling[J].Cell Death Dis,2021,12:537.doi:10.1038/s41419-021-03819-0.
[12] 彭友多,王宏伟,何嘉琦,等.胰腺癌病人肿瘤组织CBX7的表达与预后的关系[J].外科理论与实践,2017,22:228-232.
[13] Meseure DD,Vacher SP,Alsibai KD,et al.Expression of anril-polycomb complexes-CDKN2A/B/ARF genes in breast tumors: identification of a two-gene (EZH2/CBX7) signature with independent prognostic value[J]. Mol Cancer Res,2016,14:623-633.

[1]	WU Kun, NIE Bo, LI Yun-tao, YANG Jin-rong, CHENG Shen-ju, LI Yan-hong, SHI Ming-xia. Peripheral blood miR-200c level predicts the occurence of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation [J]. Basic & Clinical Medicine, 2022, 42(6): 871-875.
[2]	CHEN Qian, LIU Xian, CUI Nan, ZHAI Yang. Knockout of EZH2 inhibits migration and invasion of human cervical cancer cell lines [J]. Basic & Clinical Medicine, 2022, 42(3): 395-400.
[3]	HUANG Rong, ZHANG Jian, CHE Xu. Effect of SLC4A10 expression on prognosis of patient with hepatocellular carcinoma [J]. Basic & Clinical Medicine, 2022, 42(3): 461-466.
[4]	BAI Jing, LIU Na, DING Li, LEI Li, NI Rui, YAN Shao-chun, SHAO Guo. Identification of differentially expressed genes in cervical carcinoma after radiotherapy [J]. Basic & Clinical Medicine, 2022, 42(2): 215-220.
[5]	ZHANG Chun-li, QI Jie-hua, HUAN Yu, WU Shou-le, CAI Xu-shan. Interference with ADAM17 inhibits proliferation of human cervical cancer cell line HeLa [J]. Basic & Clinical Medicine, 2022, 42(2): 255-259.
[6]	Yang Fang LI HUI MINHU. PTTG and p21 as prognostic biomarker in radiotherapy for non-functional pituitary adenomas [J]. Basic & Clinical Medicine, 2021, 41(9): 1253-1259.
[7]	WANG Yu-qian, CHEN Ya-mei, YANG Jie, LIN Yuan, LUO Ying-ying, ZHANG Shao-sen, WU Chen. Identification and analysis of key genes in association with development and progression of adenocarcinoma at the gastroesophageal junction [J]. Basic & Clinical Medicine, 2021, 41(6): 831-836.
[8]	SI Bin, ZHANG Shu-yuan, YANG Yun-yun, CHEN Yu, ZHANG Wei-li. Association of genetic variant rs3662C＞A in the gene of p21-activated kinase 2 with risk and prognosis of stroke as well as its effect on transcription activity [J]. Basic & Clinical Medicine, 2021, 41(4): 472-478.
[9]	CHEN Zhi-gang, HONG Peng, YANG Bin, TIAN Xiao-jun, WANG Guo-liang, ZHANG Shu-dong, MA Lu-lin. Constructing a risk predictive model for recurrence following nephron-sparing surgery in the treatment of clear cell renal cell carcinoma [J]. Basic & Clinical Medicine, 2021, 41(3): 409-414.
[10]	. Advances in the role of interferon-induced proteins with tetratricopeptide repeats (TPR) in digestive system tumors [J]. Basic & Clinical Medicine, 2021, 41(11): 1662-1665.
[11]	. Pathological classification and surgical prognosis of idiopathic hyperaldosteronism [J]. Basic & Clinical Medicine, 2021, 41(10): 1481-1485.
[12]	. Correlations of MGMT promoter methylation and IDH1 mutations with the clinical prognosis of malignant glioma patients [J]. Basic & Clinical Medicine, 2021, 41(10): 1476-1480.
[13]	HU Jing-jing, TONG Jin. Exploring the long-term complications of COVID-19 and its prevention through comparison with SARS and MERS [J]. Basic & Clinical Medicine, 2020, 40(7): 887-892.
[14]	Xiao-Mei YUAN. Construction and functional characterization of human recombinant adenovirus rAd-IL-23R [J]. Basic & Clinical Medicine, 2020, 40(5): 662-667.
[15]	. Analysis and prognosis of advanced esophageal cancer treated by Traditional Chinese Medicine [J]. Basic & Clinical Medicine, 2020, 40(2): 182-186.