Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (1): 126-130.
Objective: To investigate the situation of Helicobacter pylori infection in healthy people and analyze the related risk factors. Methods: Retrospective analysis was conducted on 10661 healthy subjects who underwent carbon 13C-UBT on January 1, 2019 solstice and December 30, 2020 in the affiliated hospital of North Sichuan Medical College. According to the infection status of Helicobacter pylori (H.pylori), the subjects were divided into H.pylori positive group and H.pylori negative group. Analysis H.p ylori infection and platelets (PLT), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), T3, T4, TSH, pepsinogen Ⅰ, pepsinogen II, and gastric secretion, 17, homocysteine (Hcy), uric acid (UA), the relationship between the total bilirubin (TBIL). Results: 1. The total number of positive infections: 4382, the total positive rate: 41.10%, including 2717 male positive cases, the positive rate: 25.49%; There were 1665 cases of positive infection in females, and the positive rate was 15.62%, which was higher in males than in females (P<0.05). 2. H.p ylori compared to the positive and negative groups: positive age slightly higher than negative group (P < 0.05), H.p ylori positive group in BMI, systolic pressure, diastolic blood pressure, TG, FBG, pepsinogen Ⅰ, pepsinogen Ⅱ, G-17, Hcy were higher than negative group (P < 0.05); H.p ylori positive group in HDL - C, pepsinogen Ⅰ/Ⅱ, TBIL were lower than that of negative group (P < 0.05). There was no significant difference in PLT, UA, TC, LDL-C, T3, T4 and TSH between the two groups (P>0.05). 3, DOB value height and age, FBG, pepsinogen Ⅰ, pepsinogen Ⅱ, G - 17 were positively correlated (P = 0.000); DOB values with the pepsinogen Ⅰ / Ⅱ, TBIL negatively correlated (P = 0.000). 4, further P < 0.05 parameters into binary Lojistic regression analysis, the results showed that age, BMI, FBG, TBIL, pepsinogen Ⅰ, pepsinogen Ⅱ, pepsinogen Ⅰ / Ⅱ, Hcy are a risk factor for helicobacter pylori infection (P < 0.05). Conclusion: The risk of H.pylori infection increases with age, and infection is more common in males. Binary Lojistic regression analysis showed that age, BMI, FBG, TBIL, pepsinogen Ⅰ, pepsinogen Ⅱ, pepsinogen Ⅰ / Ⅱ, Hcy are H.p ylori the risk factors of infection. Early intervention of these risk factors is expected to reduce the infection of H.pylori and provide theoretical basis for the primary prevention of gastrointestinal diseases.
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