Basic & Clinical Medicine ›› 2017, Vol. 37 ›› Issue (12): 1765-1769.

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Research progress of the correlation of Sox5 and tumor

  

  • Received:2016-12-05 Revised:2017-01-17 Online:2017-12-05 Published:2017-11-29

Abstract: Sox5 gene is located on 12p12.1, containing 29 exons, it can transcript 5 variants, thus produce 5 isoforms. L-SOX5A is an isoform relative extensive studied, its functions include regulate embryonic development, and determine cell differentiation. Sox5 was implicated in prostate cancer, breast cancer and lymphoma.

Key words: Sox family, Sox5, cell differentiation, tumor metastasis