Abstract: Objectives To examine the levels of blood eosinophil counts, total IgE and IgE autoantibodies against BP180 and BP230 in sera of bullous pemphigoid（BP）, and to analyze correlations. Methods Sera obtained from 63 BP patients were subjected to measure serum levels of total IgE, anti-BP180 IgE and anti-BP230 IgE antibodies by ELISA assays. And analyse the relevance between Blood eosinophils/ bullous pemphigoid disease area index(BPDAI) scores and IgE autoantibodies. Results Total IgE, IgE anti-BP180 and IgE anti-BP230 antibodies were positive in 41 (65.08%),37 (58.73%) and 47 (74.60%) case of BP patient respectively. Anti-BP230 IgE levels showed a strong association with total IgE（r=0.643，p<0.001）. Of 63 patients with BP, 34 were recorded blood eosinophil counts. Blood eosinophils increased in 19 patients (55.88%). Anti-BP180 IgE were significantly correlated with urticarial/erythema scores（r=0.934，p＜0.05）. Conclusions IgE plays a role in the pathogenesis of BP. IgE autoantibodies may primarily target to BP230. Anti-BP180 IgE may effect on the urticarial lesions.

Key words: bullous pemphigoid, IgE, anti-BP180 IgE, anti-BP230 IgE