Basic & Clinical Medicine ›› 2016, Vol. 36 ›› Issue (4): 547-551.

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Advances in oncolytic adenovirus antitumor therapy


  • Received:2015-08-24 Revised:2015-11-05 Online:2016-04-05 Published:2016-03-29

Abstract: Oncolytic adenovirus is a category of adenovirus which is reconstructed by genetic engineering. The adenovirus can infect and replicate in a selective and specifical manner until the tumor cell is destroyed, while it is harmless to normal cells during the process. A bulk of strategies, hitherto, have been attempted for improving the antitumor activity and safety of oncolytic adenovirus in treatment of cancer, including altering the way of transduction, utilizing tumor-specific promoter and enhancer control of the expression of therapeutic gene as well as combining with the radiotherapy, chemotherapy or immunotherapy for synergistic effect.

Key words: oncolytic adenovirus, target therapy, cancer