Abstract: Notch signaling pathway is a highly conservative signaling pathway, which plays a key role in regulation of cell differentiation, proliferation and apoptosis, as well as a series of physiological and pathological processes. Notch signaling was frequently found to be mutation of abnormal expression and activation in hepatocellular carcinoma(HCC), which promoted the development of HCC through a variety of mechanisms and closely related to the invasion, metastasis and prognosis of HCC. Thus, Notch signaling may become a new target for treatment of HCC, providing new directions and opportunities for HCC.

Key words: Notch, signaling, hepatocellular carcinoma