Basic & Clinical Medicine ›› 2015, Vol. 35 ›› Issue (2): 266-269.

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Progress of Wnt signaling pathway and non-small cell lung cancer

  

  • Received:2014-05-26 Revised:2014-07-24 Online:2015-02-05 Published:2015-01-23

Abstract: Wnt signaling pathway alterations are prominent in human malignancies.Wnt signaling is important in non-small cell lung cancer cell lines, and Wnt inhibition reduces proliferation. Wnt signaling substantially impacts NSCLC tumorigenesis, prognosis,and resistance to therapy. Wnt pathway as a therapeutic option in advanced NSCLC.

Key words: non-small cell lung cancer, wnt signaling Pathway, prognosis, drug resistance