Basic & Clinical Medicine ›› 2014, Vol. 34 ›› Issue (10): 1434-1437.

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Research progress on immunomodulatory effects of ICOS/ICOSL and related diseases

  

  • Received:2013-12-24 Revised:2014-03-25 Online:2014-10-05 Published:2014-09-25

Abstract: Inducible co-stimulator(ICOS)and its ligand(ICOSL)play an important role in the response and regulation of immune system. It shows that ICOS bind to ICOSL relating to self-immune diseases and tumour. Targeted interventions of ICOS/ICOSL will provide new approaches for prevention and therapy of clinical diseases.

Key words: ICOS/ICOSL, immunomodulatory, diseases