Progress of CD8+CD25+regulatory T cells in diseases

doi:10.16352/j.issn.1001-6325.2022.12.1939

Abstract

Abstract: CD8⁺CD25⁺Treg can inhibit immune response and induce immune tolerance. This article reviews the changes and underlying mechanisms of CD8⁺CD25⁺Treg in pathogenesis of malignant tumors, autoimmune diseases and other common diseases such as asthma, allergic diseases, type 2 diabetes, and pre-eclampsia. The changes of CD8⁺CD25⁺Treg in different diseases are inconsistent, cell counting increased in malignant diseases but decreased in autoimmune diseases. Further understanding of CD8⁺CD25⁺Treg would supporte a basis for the prevention, treatment and improving prognosis of these diseases.

Key words: CD8⁺CD25⁺Treg, CD8⁺ Treg, regulatory T cells, autoimmune diseases, tumors

CLC Number:

WEN Li-na, CHEN Li, DUAN Rui, LI Fang. Progress of CD8⁺CD25⁺regulatory T cells in diseases[J]. Basic & Clinical Medicine, 2022, 42(12): 1939-1944.

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Progress of CD8⁺CD25⁺regulatory T cells in diseases

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