Basic & Clinical Medicine ›› 2009, Vol. 29 ›› Issue (9): 905-907.

• 研究论文 • Previous Articles     Next Articles

Deletion of gr/gr-DAZ1/DAZ2 gene and male infertility

Zhou-cun A, Li XU   

  1. Department of Biology and Chemistry,Dali College
  • Received:2008-09-19 Revised:2008-11-11 Online:2009-09-20 Published:2009-09-20
  • Contact: Zhou-cun A,

Abstract: Objective To study the relationship between the gr/gr-DAZ1/DAZ2 gene deletion and male infertility in Chinese population. Methods Distribution of gr/gr-DAZ1/DAZ2 gene deletion was investigated in 364 infertile men and 287 fertile controls using polymerase chain reaction(PCR) and fragment length polymorphism analysis (RFLP). Results gr/gr-DAZ1/DAZ2 gene deletion was detected in both infertile men and controls, but the incidence of gr/gr-DAZ1/DAZ2 gene deletion in infertile men was significantly higher than that in controls (%9.3 vs. 2.8%, P<0.001). Conclusion Deletion of gr/gr-DAZ1/DAZ2 gene is not a direct etiology but a risk factor of male infertility, suggesting that it is not essential to detect this deletion during gene diagnosis for male infertility in Chinese.

Key words: DAZ gene, Deletion, Male infertility

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