Abstract: Object To establish a safe and effective method to obtain fetus of rhesus monkey. Method The pregnant days of rhesus monkey was identified by B ultrasonography, and the pregnant rhesus monkeys in different stages of pregnant were chosen randomly. Mifepristone was subcutaneously injected to pregnant rhesus while misoprostol was put to their posterior fornix. The effect of this method was evaluated by the results of bishop score ,the rate of pregnancy termination and the quality of total RNA extracted from brain samples of rhesus fetus. Result The scores of bishop score and rates of fetus delivery of experiment group were both higher than control group (P<0.05) ,and the quality of total RNA extracted from brain samples of rhesus fetus are well. Conclusion Combined application of misoprostol and mifepristone can effective and safely obtain samples of rhesus fetus.

Key words: rhesus monkey, mifepristone, misoprostol