Abstract: Objective To investigate the distribution of Alpha2-HS glycoprotein ( AHSG) gene polymorphisms and the relationships of AHSG gene polymorphisms with atherosclerosis and serum bone relative biochemical markers. Methods Blood samples of 342 patient-in female patients, aged 20～80, were collected serum bone alkaline phosphatase, cross-linked N-telopep tide of collagen typeⅠ, cross-linked C-telopep tide of collagen type Ⅰ, osteoprotegrin and leptin were determined by ELISA. Serum TC、TG and calcium content were detected.Polymorphisms of AHSG gene were detected by polymerase chain reaction fragment length polymorphisms ( PCR-RFLP) of restriction enzyme Sac I. BMD (Norland XR-36) of the anteroposterior spine (AP) , supine lateral spine (Lat) , and femoral neck ( FN) were measured. Morphological changes in the aorta and bone of type GG patient were detected by pathological section. IMT were measured by Color Doppler Ultrasound equipment（SEQUOIA512）.Results　(1) The genotype frequency of CC, CG, and GG were 59.7% , 25.1% and 15.2% respectively in all elderly females patients.There were significant differences in blood lipids，Ca2＋ and serum bone relative biochemical markers to different AHSG genotypes. (2)There were significant differences in the BMD of the AP, Lat, FN and IMT and the serum biochemical markers among the CC，CG and GG genotypes. (3)GG-female patients bone tissue pathology section verify the AHSG polymorphism genetic mutation and atherosclerosis, osteoporosis development of the relationship.Conclusions There were closely related among AHSG polymorphism variation and the incidence of arteriosclerosis and osteoporosis in elderly female.