Basic & Clinical Medicine ›› 2008, Vol. 28 ›› Issue (8): 816-819.
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Ning-hua SHI Zhi-jian ZHANG Yan XU Dong-lin WANG Zhi-qiang ZHOU
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Abstract: Objective To study the expressions of tyrosine kinase A (TrkA) and nerve growth factor (NGF) on cochlear corti in rats after whole cerebral ischemia-reperfusion. Methods Establishing a model of whole cerebral ischemia-reperfusion in rats; examining the expressions of TrkA and NGF on cochleas assuming the method of immunohistochemistry stain; and examining the time and distribution of the cochlear hair cell apoptosis using the terminal deoxynucleotidyl transferasemediated dUTP nick end labeling (TUNEL). Results After ischemia-reperfusion the 6h NGF expression increased, the 24h NGF expression reached the highest and then restored gradually. After ischemia-reperfusion the 24h-7d TrkA expression weakened or even didn't expresse. During 3-7d the cochlear hair cells presented with apoptoses. During 7-14d TrkA expression restroed gradually. Conclusion TrkA expression is significant for mediating NGF to promote the sensory nerve cell surviving and for the biological effects of the repair of injury.
Ning-hua SHI Zhi-jian ZHANG Yan XU Dong-lin WANG Zhi-qiang ZHOU. Expression changes of TrkA and NGF in cochleas of rats after whole cerebral ischemia-reperfusion[J]. Basic & Clinical Medicine, 2008, 28(8): 816-819.
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