Abstract: Objective　PPAR-γ is acknowledgedly one of members of peroxisome proliferator activated receptors family, and acts by regulating a wide spectrum of biological activities such as carbohydrate metabolism, cell mobility, differentiation, apoptosis and so on. Of course, the above activities occur in liver regeneration. This study aims to investigate the possible contribution of PPAR-γ coupled signaling pathways to rat liver regeneration (LR) at transcription level. Methods　The above signaling pathways-related genes were obtained by collecting database data and retrieving pertinent literatures. The gene expression changes during LR was checked by Rat Genome 230 2.0 array, and LR-associated genes were identified by comparing gene expression difference between partial hepatectomy (PH) and sham operation (SO) groups．Results　64 genes were found to be LR-associated. The number of initially and totally expressed genes occurring in initiation phase of LR, G0/G1 transition, cell proliferation, cell differentiation and structure-function reconstruction was 28, 4, 34, 2 and 72, 41, 247, 90 respectively, illustrating the related-genes were initially expressed mainly in initial phase and functioned in different phases. Classification of their expression patterns into 11 groups reflected diversity and complexity of gene expression alteration in LR. Conclusion　It was inferred that PPAR-γ coupled signaling pathways maybe promote glycogen synthesis in forepart, prophase and anaphase of LR, cell proliferation and migration in the whole LR, while inhibits inflammation during LR.