Basic & Clinical Medicine ›› 2008, Vol. 28 ›› Issue (5): 512-515.

• 短篇综述 • Previous Articles     Next Articles

Research progress on the DNA vaccine of HSP70 fused with tumor antigen gene

Jin-bao ZONG, Xue-mei XU   

  1. Institute of Basic Medical Sciences, CAMS & PUMC Institute of Basic Medical Sciences, CAMS & PUMC
  • Received:2001-09-17 Revised:2007-11-01 Online:2008-05-25 Published:2008-05-25
  • Contact: Xue-mei XU

Abstract: A variety of heat shock protein 70(HSP70)-associated therapeutic vaccines have been developed in anti-tumor immunotherapy, including protein vaccine, peptide vaccine, tumor cell vaccine and DNA vaccine, etc, in which HSP70-fused DNA vaccine attracts our attention with its superiority, it not only induces consistent anti-tumor immune response but also helps sustain immune memory. In this article we reviewed the function and application of HSP70 in the therapeutic tumor DNA vaccine.