Abstract: Parkinson's disease（PD） is a progressive neurodegenerative disorder affecting mainly the elderly. Astrocyte may be involved in the pathogenesis of PD. On the one hand, it may play a protective role in PD by releasing neurotrophic factors and glutathione to support the survival of dopaminergic neurons. On the other hand, astrocyte may also release proinflammatory cytokines to promote the development of PD.