Progress in the role of NR4A1 in the development of diabetic nephropathy

doi:10.16352/j.issn.1001-6325.2023.10.1608

Abstract

Abstract: As a member of the nuclear receptor subfamily, NR4A1 works with glycerol kinase, a key glucose and lipid metabolism enzyme, to lower blood glucose and boost blood lipids and maintain glucose and lipid homeostasis, while NR4A1 deficiency leads to disruption of hepatic glucose and lipid metabolism. NR4A1 is involved in maintaining the dynamic balance of oxide and antioxidants, reducing inflammatory responses, and promoting autophagy, among other activities. Since NR4A1 is closely related to the occurrence of diabetic nephropathy and other diseases,it has aroused widespread concern in recent years.

Key words: NR4A1, diabetic nephropathy

CLC Number:

R587.2

LYU Wenyue, LI Jinmeng, LI Han, LIU Lei, WANG Na. Progress in the role of NR4A1 in the development of diabetic nephropathy[J]. Basic & Clinical Medicine, 2023, 43(10): 1608-1611.

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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2023.10.1608

http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2023/V43/I10/1608

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